Rybelsus Semaglutide Oral Injection Side Effects, Interactions, Uses, Dosage, Warnings

The manufacturer of Rybelsus didn’t report how often side effects occurred in people taking 3-milligram (mg) doses of this drug. But there were differences reported between people taking 7-mg doses and 14-mg doses. Don’t take Rybelsus with food, beverages (besides water), or other medications that are taken by mouth. If your doctor diagnoses you with pancreatitis, you won’t be able to take Rybelsus again. Instead, your doctor will prescribe another diabetes medication for you to replace Rybelsus.

Rybelsus tablets work to lower blood sugar (glucose) levels by increasing how much insulin is released and decreasing glucagon secretion. Rybelsus is from the class of medicines called GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonist). Rybelsus has demonstrated a significant impact on weight loss in individuals with type 2 diabetes.​ Clinical studies have shown that patients taking Rybelsus experienced greater weight loss compared to those on placеbo. Beyond weight loss and diabetes, researchers are also investigating a growing list of conditions GLP-1 agonists could help treat.

Rybelsus and other medications

After 30 days, your doctor will likely raise your dose to help you achieve your blood sugar goals. If after another 30 days, you haven’t reached your goal, your doctor may raise your Rybelsus dose again. Rybelsus and Ozempic are both brand-name medications that contain the active drug semaglutide. Unlike Rybelsus, which is taken by mouth, Ozempic is taken by injection. Also, talk with your doctor about the diabetes treatment plan that’s right for you.

  • Rybelsus (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
  • Rybelsus also has warnings about pancreatitis (inflammation of the pancreas), diabetic retinopathy (damage to the eye’s retina), hypoglycemia (low blood sugar), acute kidney injury and hypersensitivity reactions.
  • The mean baseline body weight was 88.6 kg, 89.0 kg and 88.1 kg in the placebo, RYBELSUS 7 mg, and RYBELSUS 14 mg arms, respectively.
  • The weight loss may be a result of better blood sugar management, in addition to changes in diet and exercise.
  • Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

More studies are needed to show whether the medication is safe and effective for this age group. Learn the symptoms of high and low blood sugar and how to treat low blood sugar. Attend a diabetes education program to learn more about how to manage your diabetes with medications, diet, exercise, and regular medical exams.


Manufacturer list prices are around $900 or more (and retail prices even higher) for about a month’s supply of any of the GLP-1 agonists that are widely used in the U.S. Insurance companies are more likely to cover the drugs if they’re used to treat diabetes than if they’re used for weight loss—a frustration for people without diabetes who seek the benefits of weight loss. “I don’t buy rybelsus tablets want them to lose a whole bunch of weight,” she says. The human gut naturally produces a hormone called GLP-1 in response to eating. Rybelsus is the only oral form of this powerful diabetes and weight loss medication. It has been shown to grant both weight loss and blood sugar improvements in many different populations, both alone and in combination with other diabetes drugs.

How should I take Rybelsus?